|
KMID : 0370219980420050540
|
|
Yakhak Hoeji
1998 Volume.42 No. 5 p.540 ~ p.543
|
|
|
of Nitric Oxide Synthesis by 8-epi-xanthatin in Activated RAW 264.7 Cells
|
|
이화진/Lee HJ
정연수/유시용/류재하/Jeong YS/Ryu SY/Ryu JH
|
|
|
Abstract
|
|
|
|
The nitric oxide (NO) produced in large amounts by inducible nitric oxide synthase is known to be responsible for the vasodilation and hypotension observed in septic shock. We have found that 8-epi-xanthatin from Xanthium strumarium L. inhibited the production of NO in LPS-activated RAW 264.7 cells (IC50 value was 1.5 mcM). This activity was resulted from the suppressing of inducible nitric oxide synthase enzyme expression.
|
|
|
KEYWORD
|
|
|
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|